RNA Research · Biomarker Discovery · Therapeutic Development
Ribo-Therapeutics develops precision research kits for ribosome profiling and circular RNA isolation — giving scientists the resolution to map translation and discover novel RNA biology at scale.
Research kits
Our kit platforms are designed around the real workflow pain points in ribo-seq and circular RNA research — from library prep to bioinformatic-ready output.
RT-K001
RiboMap Pro Kit
Complete ribosome profiling kit for genome-wide translation mapping. RNase I footprinting, rRNA depletion, and RPF library construction in a single optimized workflow.
RT-K002
CircIso Discovery Kit
A completely new platform for circular RNA isolation and identification — built on proprietary chemistry that does not rely on RNase R digestion. Enables highly specific circRNA enrichment and back-splice junction identification with superior sensitivity and reduced linear RNA background.
Technology platforms
Our core innovation is a completely new approach to circRNA isolation that moves beyond existing enzymatic limitations — paired with a best-in-class ribo-seq platform engineered for clean, high-yield RPF libraries. Every kit ships with internal QC controls and a companion analysis pipeline.
Platform 01
Ribo-Seq Platform
Optimized RNase I footprinting with proprietary rRNA subtraction chemistry. Generates clean RPF libraries with >85% on-target reads. Compatible with STAR, HISAT2, and Bowtie2 pipelines.
Platform 02
CircRNA Isolation & ID Platform
A completely new proprietary platform for circRNA enrichment and identification — independent of RNase R digestion. Achieves high-specificity isolation of circular RNAs with BSJ-targeted identification across >10,000 annotated junctions and de novo circRNA discovery.
Data Support
QC & Data Direction
Our kits ship with built-in quality control checkpoints and recommended analytical workflows. We guide researchers on RPF library assessment, BSJ output interpretation, and alignment tool selection — ensuring your data is clean, reliable, and analysis-ready from day one.
The science
Ribo-Therapeutics is built on two proprietary platforms — ribosome profiling for genome-wide translation mapping, and a completely new circRNA isolation chemistry that identifies back-splice junctions with unmatched specificity.
Ribo-seq · RT-K001
Ribosome profiling captures genome-wide snapshots of active translation by sequencing ribosome-protected mRNA fragments (RPFs). Our RiboMap Pro kit resolves codon-level occupancy with single-nucleotide precision — revealing translational regulation invisible to RNA-seq alone.
CircIso · RT-K002
Circular RNAs are covalently closed molecules formed by back-splicing — where a downstream exon donor joins back to an upstream exon acceptor, creating the back-splice junction (BSJ). Our CircIso platform isolates and identifies these molecules using completely new proprietary chemistry, without reliance on RNase R digestion.
News & Milestones
"A quick and simplified method for isolation of ribosome-protected mRNA fragments for translatome identification"
Awarded Phase I funding to develop and validate our ribosome profiling kit — establishing a streamlined workflow for genome-wide translation mapping from low-input samples.
"A quick, robust and unbiased platform for circular RNA isolation, discovery and profiling"
Awarded Phase I funding to advance our novel circRNA isolation chemistry — validating a platform that identifies back-splice junctions without reliance on conventional enzymatic approaches.
We are actively investing in our platforms and pursuing additional funding to accelerate kit development and commercialization.
Connect
We are selectively partnering with academic core facilities, pharma R&D groups, and life science distributors. Beta kit access is available now for qualified labs.